GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs11976180 | 1 | rs2371247 | chr7:143764179 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.97 | 5.43E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2371248 | chr7:143764189 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.3E-9 | Obesity-related traits |
| BLCA | cis | rs9815354 | 1 | rs2371623 | chr3:41761083 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.9 | 9.78E-21 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs2371627 | chr3:41839219 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.96 | 6.32E-21 | Diastolic blood pressure |
| BLCA | cis | rs10935120 | 1 | rs2373865 | chr3:134291556 | ANAPC13 | chr3:134196547-134204865:- | -0.51 | -8 | 1.45E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs2373865 | chr3:134291556 | CEP63 | chr3:134204575-134293852:+ | -0.24 | -4.14 | 4.32E-5 | Height |
| BLCA | cis | rs12220238 | 1 | rs2395077 | chr10:75932001 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.53 | 7.84E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs9457247 | 1 | rs239935 | chr6:167411788 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -4.94 | 1.19E-6 | Crohn's disease |
| BLCA | cis | rs2404602 | 1 | rs2404602 | chr15:77030792 | SCAPER | chr15:76640529-77197744:- | -0.18 | -3.86 | 0.000134 | Blood metabolite levels |
| BLCA | cis | rs2404602 | 1 | rs2404740 | chr15:76852143 | SCAPER | chr15:76640529-77197744:- | -0.22 | -4.75 | 2.88E-6 | Blood metabolite levels |
| BLCA | cis | rs2404602 | 1 | rs2404741 | chr15:76851735 | SCAPER | chr15:76640529-77197744:- | -0.22 | -4.75 | 2.88E-6 | Blood metabolite levels |
| BLCA | cis | rs4141404 | 1 | rs2413049 | chr22:31686144 | C22orf30 | chr22:32072242-32146120:- | -0.21 | -3.89 | 0.000117 | Paclitaxel-induced neuropathy |
| BLCA | cis | rs2243480 | 1 | rs2420170 | chr7:65656053 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.75 | 2.86E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs2420171 | chr7:65637760 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs9309473 | 1 | rs2421555 | chr2:73816955 | ALMS1P | chr2:73872046-73912692:+ | 0.39 | 5.73 | 2.03E-8 | Metabolite levels |